Haplotype analysis of distantly related populations implicates corneodesmosin in psoriasis susceptibility.

@article{Capon2003HaplotypeAO,
  title={Haplotype analysis of distantly related populations implicates corneodesmosin in psoriasis susceptibility.},
  author={Francesca Capon and I K Toal and Julie Claire Evans and Michael Hugh Allen and Shanta Patel and D Tillman and Donald Burden and Jonathan N. W. N. Barker and Richard C Trembath},
  journal={Journal of medical genetics},
  year={2003},
  volume={40 6},
  pages={447-52}
}
Psoriasis (MIM *177900) is a hyperproliferative skin disorder, characterised by inflammatory cell dermal infiltration, disruption of keratinocyte terminal differentiation, and premature desquamation of the stratum corneum. Although the disease pathogenesis is poorly understood, it is well recognised that genetic factors underlie psoriasis susceptibility, as documented by family clustering of the disease and increased concordance rates in monozygotic twin pairs. 3 To date, genome wide scans have… CONTINUE READING

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