Haplotype analysis of VDR gene polymorphisms: a meta-analysis

  title={Haplotype analysis of VDR gene polymorphisms: a meta-analysis},
  author={Ammarin Thakkinstian and Catherine D’Este and John Attia},
  journal={Osteoporosis International},
Introduction: Although many studies have addressed the relationship between multiple individual polymorphisms in the vitamin D receptor (VDR) gene and bone health, few have analyzed this data in terms of haplotypes. We performed a meta-analysis of studies with data on the BsmI, ApaI, and TaqI polymorphisms in order to (a) estimate haplotype frequencies, (b) determine linkage disequilibrium (LD), and (c) estimate the magnitude of the association between haplotypes and osteoporosis/bone mineral… CONTINUE READING
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