Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent

@article{Cavallone2007HaplotypeAO,
  title={Haplotype analysis of TP53 polymorphisms, Arg72Pro and Ins16, in BRCA1 and BRCA2 mutation carriers of French Canadian descent},
  author={Luca Cavallone and Suzanna L. Arcand and Christine M. Maugard and Parviz Ghadirian and Anne-Marie Mes-Masson and Diane Mich{\`e}le Provencher and Patricia N. Tonin},
  journal={BMC Cancer},
  year={2007},
  volume={8},
  pages={96 - 96}
}
The TP53 polymorphisms Arg72Pro (Ex4+199 G>C) and Ins16 (IVS3+24 ins16) have been proposed to modify risk of breast cancer associated with germline BRCA1 and BRCA2 mutations. Allele frequencies of these polymorphisms were investigated to determine if they modify risk in BRCA mutation carriers in breast cancer cases drawn from French Canadian cancer families, a population shown to exhibit strong founder effects. The frequencies of the TP53 alleles, genotypes and haplotypes of 157 index breast… CONTINUE READING

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