Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.

@article{Ma2005HaplotypeAI,
  title={Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.},
  author={Jennie Z Ma and Joke Beuten and Thomas J. Payne and Randolph T. Dupont and Robert C. Elston and Ming D. Li},
  journal={Human molecular genetics},
  year={2005},
  volume={14 12},
  pages={1691-8}
}
DOPA decarboxylase (DDC; also known as L-amino acid decarboxylase; AADC) is involved in the synthesis of dopamine, norepinephrine and serotonin. Because the mesolimbic dopaminergic system is implicated in the reinforcing effects of many drugs, including nicotine, the DDC gene is considered a plausible candidate for involvement in the development of vulnerability to nicotine dependence (ND). Further, this gene is located within the 7p11 region that showed a 'suggestive linkage' to ND in our… CONTINUE READING
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