Haplotype Analysis of GSK-3β Gene Polymorphisms in Bipolar Disorder Lithium Responders and Nonresponders

@inproceedings{Iwahashi2014HaplotypeAO,
  title={Haplotype Analysis of GSK-3β Gene Polymorphisms in Bipolar Disorder Lithium Responders and Nonresponders},
  author={Kazuhiko Iwahashi and Daisuke Nishizawa and Shin Narita and Maki Numajiri and Ohoshi Murayama and Eiji Yoshihara and Yuuya Onozawa and Kenta Nagahori and Fumihiko Fukamauchi and Kazutaka Ikeda and Jun Ishigooka},
  booktitle={Clinical neuropharmacology},
  year={2014}
}
The GSK-3β gene, GSK3B, codes for an enzyme that is a target for the action of mood stabilizers, lithium and possibly valproic acid.In this study, the relationship between haplotypes consisting of single nucleotide polymorphisms (SNPs) of GSK3B -50T/C and -1727A/T and the effect of lithium was studied among Japanese bipolar disorder lithium nonresponders and responders.The distributions of the GSK3B haplotypes (-50T/C and -1727A/T) showed a trend for significant difference between the lithium… CONTINUE READING
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