Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure

@article{Chang2001HaploinsufficientBO,
  title={Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure},
  author={B. -Y. Chang and Richard S. Smith and Maureen A Peters and Olga V Savinova and Norman L. Hawes and Adriana Zabaleta and Steven Nusinowitz and Janice E Martin and Muriel T. Davisson and Constance L. Cepko and Brigid M. L. Hogan and Simon John},
  journal={BMC Genetics},
  year={2001},
  volume={2},
  pages={18 - 18}
}
Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment dysgenesis and glaucoma in most of these families are not identified and the affected developmental processes are poorly understood. Bone morphogenetic proteins (BMPs) participate in various developmental processes. We tested the importance of Bmp4 gene dosage for ocular development and… CONTINUE READING