Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish.

Abstract

RATIONALE Although a cardioprotective function of target of rapamycin (TOR) signaling inhibition has been suggested by pharmacological studies using rapamycin, genetic evidences are still lacking. We explored adult zebrafish as a novel vertebrate model for dissecting signaling pathways in cardiomyopathy. OBJECTIVE We generated the second adult zebrafish… (More)
DOI: 10.1161/CIRCRESAHA.111.248260

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@article{Ding2011HaploinsufficiencyOT, title={Haploinsufficiency of target of rapamycin attenuates cardiomyopathies in adult zebrafish.}, author={Yonghe Ding and Xiaojing Sun and Wei Huang and Tiffany R. Hoage and Margaret M. Redfield and Sudhir Shyam Kushwaha and Sridhar Sivasubbu and Xueying Lin and Stephen C. Ekker and Xiaolei Xu}, journal={Circulation research}, year={2011}, volume={109 6}, pages={658-69} }