Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons

@article{Cho2009HaploinsufficiencyOR,
  title={Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons},
  author={K-in Cho and Hong Yi and Alex Yeh and Nomingerel Tserentsoodol and Laura Cuadrado and Kelly Searle and Yanyan Hao and Paulo A. Ferreira},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={287-297}
}
Prolonged light exposure is a determinant factor in inducing neurodegeneration of photoreceptors by apoptosis. Yet, the molecular bases of the pathways and components triggering this cell death event are elusive. Here, we reveal a prominent age-dependent increase in the susceptibility of photoreceptor neurons to undergo apoptosis under light in a mouse model. This is accompanied by light-induced subcellular changes of photoreceptors, such as dilation of the disks at the tip of the outer… CONTINUE READING