Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.

@article{Uhl2003HaploinsufficiencybasedLF,
  title={Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C.albicans.},
  author={MIMDCOMPUTERSA. Uhl and Matt Biery and Nancy Craig and Alexander Johnson},
  journal={The EMBO journal},
  year={2003},
  volume={22 11},
  pages={2668-78}
}
Candida albicans is the most prevalent human fungal pathogen. Here, we take advantage of haploinsufficiency and transposon mutagenesis to perform large-scale loss-of-function genetic screen in this organism. We identified mutations in 146 genes that affect the switch between its single-cell (yeast) form and filamentous forms of growth; this switch appears central to the virulence of C.albicans. The encoded proteins include those involved in nutrient sensing, signal transduction, transcriptional… CONTINUE READING
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Many of the genes required for mating in Saccharomyces cerevisiae are also required for mating in Candida albicans

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