Haploidentical stem cell transplantation in leukemia

  title={Haploidentical stem cell transplantation in leukemia},
  author={Franco Aversa and Andrea Velardi and Antonio Tabilio and Yair Reisner and M F Martelli},
  journal={Blood reviews},
  volume={15 3},
In acute leukemia patients, infusing a megadose of extensively T-cell-depleted hematopoietic stem cells after an immuno-myeloablative conditioning regimen ensures sustained engraftment of full-haplotype mismatched transplants without graft-vs-host disease. Besides the conditioning regimen and the megadose of stem cells donor natural killer cell alloreactivity also plays a role in facilitating engraftment and in preventing relapse. Since our first successful pilot study, our efforts have… CONTINUE READING


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