Haploidentical peripheral blood stem cell transplantation without irradiation or busulfan after reduced-intensity conditioning for KMT2A(MLL)-rearranged infant B-cell precursor acute lymphoblastic leukemia: Report of two cases.

@article{Yoshimi2017HaploidenticalPB,
  title={Haploidentical peripheral blood stem cell transplantation without irradiation or busulfan after reduced-intensity conditioning for KMT2A(MLL)-rearranged infant B-cell precursor acute lymphoblastic leukemia: Report of two cases.},
  author={Ai Yoshimi and Keisuke Kato and Sho Hosaka and Ryoko Suzuki and Hiroko Fukushima and Tomohei Nakao and Chie Kobayashi and Takashi Fukushima and Kazutoshi Koike and Ryo Sumazaki and Masahiro Tsuchida},
  journal={Pediatric transplantation},
  year={2017},
  volume={21 4}
}
We present two infants with KMT2A(MLL)-gene-R-associated BCP-ALL, who received HLA haploidentical PBSCT after RIC. The patients developed ALL at age 6 months and 3 months, respectively. Case 1 underwent PBSCT at the second CR with detectable KMT2A-AFF1(MLL-AF4) fusion gene transcript at 11 months of age, and Case 2 at the first CR without KMT2A-MLLT1(MLL… CONTINUE READING