Haplodeficiency of Klotho Gene Causes Arterial Stiffening via Upregulation of Scleraxis Expression and Induction of Autophagy.

@article{Chen2015HaplodeficiencyOK,
  title={Haplodeficiency of Klotho Gene Causes Arterial Stiffening via Upregulation of Scleraxis Expression and Induction of Autophagy.},
  author={Kai Chen and XiaoLi Zhou and Zhongjie Sun},
  journal={Hypertension},
  year={2015},
  volume={66 5},
  pages={1006-13}
}
The prevalence of arterial stiffness increases with age, whereas the level of the aging-suppressor protein klotho decreases with age. The objective of this study is to assess whether haplodeficiency of klotho gene causes arterial stiffness and to investigate the underlying mechanism. Pulse wave velocity, a direct measure of arterial stiffness, was increased… CONTINUE READING