Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.

@article{Mo2010HapalindolerelatedAF,
  title={Hapalindole-related alkaloids from the cultured cyanobacterium Fischerella ambigua.},
  author={Shunyan Mo and Aleksej Krunic and Bernard D Santarsiero and Scott G Franzblau and Jimmy Orjala},
  journal={Phytochemistry},
  year={2010},
  volume={71 17-18},
  pages={2116-23}
}
Four hapalindole-related alkaloids, namely fischambiguines A and B, ambiguine P, ambiguine Q nitrile as well as ambiguine G nitrile were identified from the cultured cyanobacterium Fischerella ambigua (UTEX 1903). The structures were determined by spectroscopic analysis including MS, 1D and 2D NMR and X-ray crystallography. The alkaloids possessed fused pentacyclic and hexacyclic carbon skeletons. Fischambiguine B displayed a strong inhibitory activity against Mycobacterium tuberculosis with an… CONTINUE READING

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