Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells.

@article{Markotic2003HantavirusesIC,
  title={Hantaviruses induce cytopathic effects and apoptosis in continuous human embryonic kidney cells.},
  author={Antonio Markotic and Lucinda Hensley and Tom Geisbert and Kristin W. Spik and Connie S. Schmaljohn},
  journal={The Journal of general virology},
  year={2003},
  volume={84 Pt 8},
  pages={
          2197-202
        }
}
Hantaviruses are maintained in nature in persistently infected rodents and can also persistently infect cultured mammalian cells, causing little or no cytopathology. An unexpected outcome of this study was the observation of cytopathic effects (CPE) in the hantavirus-infected human embryonic kidney cell line HEK293. It was confirmed that hantaviruses induce apoptosis in HEK293 cells, although apoptosis appeared mostly in uninfected, bystander cells and rarely in infected HEK293 cells. Although… CONTINUE READING

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