Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability.

@article{Gavrilovskaya2008HantavirusesDE,
  title={Hantaviruses direct endothelial cell permeability by sensitizing cells to the vascular permeability factor VEGF, while angiopoietin 1 and sphingosine 1-phosphate inhibit hantavirus-directed permeability.},
  author={Irina N. Gavrilovskaya and Elena E. Gorbunova and Natalie A Mackow and Erich R. Mackow},
  journal={Journal of virology},
  year={2008},
  volume={82 12},
  pages={5797-806}
}
Hantaviruses infect human endothelial cells and cause two vascular permeability-based diseases: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. Hantavirus infection alone does not permeabilize endothelial cell monolayers. However, pathogenic hantaviruses inhibit the function of alphav beta3 integrins on endothelial cells, and hemorrhagic disease and vascular permeability deficits are consequences of dysfunctional beta3 integrins that normally regulate permeabilizing… CONTINUE READING

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Using the hantavirus permeability assay we further demonstrate that the endothelial - cell - specific growth factor angiopoietin 1 ( Ang-1 ) and the platelet - derived lipid mediator sphingosine 1-phosphate ( S1P ) inhibit hantavirus directed endothelial cell permeability at physiologic concentrations .
Using the hantavirus permeability assay we further demonstrate that the endothelial - cell - specific growth factor angiopoietin 1 ( Ang-1 ) and the platelet - derived lipid mediator sphingosine 1-phosphate ( S1P ) inhibit hantavirus directed endothelial cell permeability at physiologic concentrations .
Hantaviruses infect human endothelial cells and cause two vascular permeability - based diseases : hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome .
Hantaviruses infect human endothelial cells and cause two vascular permeability - based diseases : hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome .
Using the hantavirus permeability assay we further demonstrate that the endothelial - cell - specific growth factor angiopoietin 1 ( Ang-1 ) and the platelet - derived lipid mediator sphingosine 1-phosphate ( S1P ) inhibit hantavirus directed endothelial cell permeability at physiologic concentrations .
Endothelial CellsConstitutional part ofEndothelium
Using the hantavirus permeability assay we further demonstrate that the endothelial - cell - specific growth factor angiopoietin 1 ( Ang-1 ) and the platelet - derived lipid mediator sphingosine 1-phosphate ( S1P ) inhibit hantavirus directed endothelial cell permeability at physiologic concentrations .
Endothelial CellsAnatomic structure is physical part ofEndothelium
Using the hantavirus permeability assay we further demonstrate that the endothelial - cell - specific growth factor angiopoietin 1 ( Ang-1 ) and the platelet - derived lipid mediator sphingosine 1-phosphate ( S1P ) inhibit hantavirus directed endothelial cell permeability at physiologic concentrations .
Using the hantavirus permeability assay we further demonstrate that the endothelial - cell - specific growth factor angiopoietin 1 ( Ang-1 ) and the platelet - derived lipid mediator sphingosine 1-phosphate ( S1P ) inhibit hantavirus directed endothelial cell permeability at physiologic concentrations .
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