Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.

@article{Li2002HantavirusNP,
  title={Hantavirus nucleocapsid protein interacts with the Fas-mediated apoptosis enhancer Daxx.},
  author={Xiaodong Li and Tomi P. M{\"a}kel{\"a} and Deyin Guo and Rabah Soliymani and Vesa Koistinen and Olli Vapalahti and Antti Vaheri and Hilkka Lankinen},
  journal={The Journal of general virology},
  year={2002},
  volume={83 Pt 4},
  pages={
          759-66
        }
}
Hantaviruses cause two severe diseases, haemorrhagic fever with renal syndrome in Eurasia and hantavirus pulmonary syndrome in the Americas. To understand more about the molecular mechanisms that lead to these diseases, the associations of Puumala virus nucleocapsid protein (PUUV-N) with cellular proteins were studied by yeast two-hybrid screening. Daxx, known as an apoptosis enhancer, was identified from a HeLa cDNA library and its interaction with PUUV-N was confirmed by GST pull-down assay… CONTINUE READING

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