Hantavirus disease outbreak in Germany: limitations of routine serological diagnostics and clustering of virus sequences of human and rodent origin.

@article{Schilling2007HantavirusDO,
  title={Hantavirus disease outbreak in Germany: limitations of routine serological diagnostics and clustering of virus sequences of human and rodent origin.},
  author={Stefan Schilling and Petra Emmerich and Boris Klempa and Brita Auste and Ebbo Schnaith and Herbert Schmitz and Detlev H. Kr{\"u}ger and Stephan G{\"u}nther and Helga Meisel},
  journal={Journal of clinical microbiology},
  year={2007},
  volume={45 9},
  pages={3008-14}
}
In Europe, hemorrhagic fever with renal syndrome results mainly from infection with Puumala virus (PUUV) or Dobrava virus. For 31 patients from a hantavirus disease outbreak in Lower Bavaria, a district in southeast Germany, serodiagnosis was undertaken by enzyme-linked immunosorbent assay, immunofluorescence assay, and immunoblot analysis. In a few of these cases, however, PUUV-specific typing of antibodies by these standard assays failed and a virus neutralization assay under biosafety level… CONTINUE READING

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