Hansemann, Boveri, chromosomes and the gametogenesis‐related theories of tumours

@article{Bignold2006HansemannBC,
  title={Hansemann, Boveri, chromosomes and the gametogenesis‐related theories of tumours},
  author={Leon P. Bignold and Brian Coghlan and Hubertus P. A. Jersmann},
  journal={Cell Biology International},
  year={2006},
  volume={30}
}
Letter to Editor
TLDR
In the early twentieth century, the directions of cancer research moved towards investigating Mendelian genetics in relation to tumours, and the mechanisms of action of viral, physical and chemical carcinogens.
Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors.
  • L. Bignold
  • Biology
    Histology and histopathology
  • 2007
TLDR
It is suggested that all three mechanisms of the genomic pathogenesis of tumors may play roles in the formation of certain tumor types, including populations which are relatively genomically stable, hyperploid and immortal.
Mutation, replicative infidelity of DNA and aneuploidy sequentially in the formation of malignant pleomorphic tumors.
TLDR
It is suggested that all three mechanisms of the genomic pathogenesis of tumors may play roles in the formation of certain tumor types, including those which are relatively genomically stable, hyperploid and immortal.
The dualistic origin of human tumors
Abnormal gametogenesis induced by p53 deficiency promotes tumor progression and drug resistance
TLDR
This study establishes the genetic evidence to support embryonal/gametogenesis theory of tumors and reveals a pivotal role of p53 in restricting abnormal gametogenesis that may represent a novel aspect for p53’s tumor suppression.
Mouse Models of Human Familial Paraganglioma
TLDR
PGLs are rare (1:300,000) tumors of neuroectodermal origin derived from paraganglia, a diffuse neuroendocrine system dispersed from the base of the skull to the pelvic floor (Baysal, 2002).
Different Aneuploidies Arise From the Same Bridge-Induced Chromosomal Translocation Event in Saccharomyces cerevisiae
TLDR
Ten morphologically and physiologically different translocants ensuing from the induction of the same bridge-induced translocation (BIT) event in the budding yeast Saccharomyces cerevisiae are described, confirming the modellistic value of the yeast BIT system for mammalian cells.
Integrating Conflicting Cancer Theories by Recognizing the Roles of Epigenetic and Genetic Alterations in the Immediate-Cancer-Causing Genes that Establish Cellular Immortality and Autonomy
TLDR
The integrated theory describes that any extracellular, intracellular, or intranuclear stressors can initiate a lengthy tumorigenesis to engender a benign or malignant tumor, but the aberrations directly establishing cellular immortality and autonomy may be epigenetic or genetic alterations in the genomic DNA.
How to count chromosomes in a cell: An overview of current and novel technologies
TLDR
In this review, an overview of several “traditional” karyotyping methods as well as the latest high throughput next generation sequencing karyotypes with their respective advantages and disadvantages are provided.
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It is concluded that it was unfair to include Boveri's name beside that of Sutton's as one of the proponents of the chromosome hypothesis of Mendelian heredity, because he did not publish any hypothesis of that kind during the relevant period (1902-1903).
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During development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process that could be important in the development of the cancer stem cell.
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TLDR
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