Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety.

@article{Andrews1993HandlingHO,
  title={Handling history of rats modifies behavioural effects of drugs in the elevated plus-maze test of anxiety.},
  author={Nick Andrews and S. E. File},
  journal={European journal of pharmacology},
  year={1993},
  volume={235 1},
  pages={109-12}
}
In rats naive to handling, but not in handling-habituated animals, baclofen (1 mg/kg) and (R,S) zacopride (1 microgram/kg) had significant anxiolytic effects, shown by an increased percentage of time spent on the open arms of the elevated plus-maze. The effects of buspirone were also modified by the animals' handling history and 200 micrograms/kg was significantly anxiogenic only in handling-habituated animals. The pattern of results is discussed in relation to biochemical differences already… CONTINUE READING

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