Handles for solid-phase peptide synthesis.

  title={Handles for solid-phase peptide synthesis.},
  author={Michael F. Songster and George Barany},
  journal={Methods in enzymology},
Publisher Summary This chapter presents a survey on handles—both standard and preformed, which have proved their usefulness over the years. The chapter emphasizes on handles developed in the laboratory that illustrate a gamut of possibilities for the C terminus produced, for the applied cleavage mechanisms , and for compatibility with N α -amino and side-chain protecting groups. The latter point is significant, because segment condensation/convergent strategies for peptide synthesis require… CONTINUE READING