Handedness in twins: joint analysis of data from 35 samples.

@article{Medland2006HandednessIT,
  title={Handedness in twins: joint analysis of data from 35 samples.},
  author={Sarah E. Medland and David L. Duffy and Margaret J. Wright and Gina Malke Geffen and Nicholas G. Martin},
  journal={Twin research and human genetics : the official journal of the International Society for Twin Studies},
  year={2006},
  volume={9 1},
  pages={
          46-53
        }
}
  • S. Medland, D. Duffy, +2 authors N. Martin
  • Published 1 February 2006
  • Psychology, Medicine
  • Twin research and human genetics : the official journal of the International Society for Twin Studies
Simultaneous analysis of handedness data from 35 samples of twins (with a combined sample size of 21,127 twin pairs) found a small but significant additive genetic effect accounting for 25.47% of the variance (95% confidence interval [CI] 15.69-29.51%). No common environmental influences were detected (C = 0.00; 95% CI 0.00-7.67%), with the majority of the variance, 74.53%, explained by factors unique to the individual (95% CI 70.49-78.67%). No significant heterogeneity was observed within… 
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Analysis of genome-wide SNP data from 3940 twins failed to identify any locus associated with handedness at a genome- wide level of significance, and this study is inadequately powered to reliably detect alleles with effect sizes corresponding to an odds ratio of 1.2, but should have good power to detect effects at an odds ratios of 2 or more.
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