Handbook of Neurochemistry and Molecular Neurobiology Schizophrenia

@inproceedings{Kantrowitz2009HandbookON,
  title={Handbook of Neurochemistry and Molecular Neurobiology Schizophrenia},
  author={Joshua T. Kantrowitz},
  year={2009}
}
This chapter is a review of the evidence implicating a dysfunction of dopamine transmission in the prefrontal cortex in schizophrenia, underlying negative symptoms and cognitive deficits. The evidence derives essentially from brain imaging studies, post-mortem studies and clinical pharmacological studies. The imaging studies have suggested alterations in the main mediator of dopamine transmission in the cortex, the D1 receptors. Furthermore, studies have suggested a link between NMDA deficits… CONTINUE READING
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