Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention

@article{Esposito2018HandFA,
  title={Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention},
  author={Susanna Esposito and Nicola Principi},
  journal={European Journal of Clinical Microbiology \& Infectious Diseases},
  year={2018},
  volume={37},
  pages={391-398}
}
  • S. EspositoN. Principi
  • Published 6 February 2018
  • Medicine, Biology
  • European Journal of Clinical Microbiology & Infectious Diseases
For a long time, hand, foot and mouth disease (HFMD) was seen as a mild viral infection characterized by typical clinical manifestations that spontaneously resolved in a few days without complications. In the past two decades, HFMD has received new attention because of evidence that this disease could have clinical, epidemiological and aetiological characteristics quite different from those initially thought. In contrast to previous beliefs, it has been clarified that HFMD can be associated… 

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References

SHOWING 1-10 OF 111 REFERENCES

Hand-foot-and-mouth disease: a new look at a classic viral rash

Atypical manifestations of HFMD in children with atopic dermatitis may mimic herpetic superinfection, and the mainstay of treatment for HMFD remains supportive care.

Dermatological Spectrum of Hand, Foot and Mouth Disease from Classical to Generalized Exanthema

Hospitalised children with confirmed HFMD have a clinical spectrum ranging from classical to generalized vesicular exanthema, and CV-A6 is associated with peri-oral rash, which is related to coxsackie virus A6 when there is an atypical rash.

Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection.

Hand, foot, and mouth disease in China, 2008-12: an epidemiological study.

Outbreak of hand, foot and mouth disease/herpangina associated with coxsackievirus A6 and A10 infections in 2010, France: a large citywide, prospective observational study.

  • A. MirandC. Henquell H. Peigue-Lafeuille
  • Medicine, Biology
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2012
A sentinel surveillance system involving paediatricians from Clermont-Ferrand (France) was set up to determine the clinical and epidemiological characteristics of HFMD/HA associated with enterovirus infections, and the outbreak described in this population survey was caused by coxsackievirus A6 and coxsacksackiev virus A10, the third dual outbreak in Europe in the last 3 years.

The Epidemiology of Hand, Foot and Mouth Disease in Asia

Knowledge on HFMD remains insufficient to guide interventions such as the incorporation of an EV-A71 vaccine in pediatric vaccination schedules, and most studies were underpowered to adjust rigorously for confounding variables.

Severe hand, foot, and mouth disease and coxsackievirus A6-Shenzhen, China.

  • Fan YangJing Yuan Q. Jin
  • Biology, Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2014
It is found that although CV-A6 was the second most common HEV in HFMD in Shenzhen in 2012, no CVA6–associated severe HFMD cases were observed in 2012 and there was a substantial increase of CV- a6– associated severe HF MD cases in 2013, which is considered a substantial public health threat.

Characterization of severe hand, foot, and mouth disease in Shenzhen, China, 2009–2013

Hand, foot, and mouth disease (HFMD) is caused by human enteroviruses, especially by enterovirus 71 (EV71) and coxsackievirus A16 (CA16). Patients infected with different enteroviruses show varied

Hand, Foot, and Mouth Disease in China: Patterns of Spread and Transmissibility

Hand, foot, and mouth disease is a moderately transmittable infectious disease, mainly among preschool children, and enterovirus 71 was responsible for most severe cases and fatalities in China.
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