Han/Wistar rats are exceptionally resistant to TCDD. I.

Abstract

Adult male Han/Wistar rats were administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intraperitoneally at doses ranging from 125 to 1400 micrograms/kg and monitored for 39 to 48 days. Two rats succumbed in the course of the experiment: one in the group receiving 625 and one dosed 1000 micrograms/kg. Body weights of the animals decreased by 20 to 30% during the first 10 to 14 days and became stable thereafter. Feed consumption decreased to 1/3-1/2 of control levels by Day 4 (calculated per metabolic body mass) and returned gradually to starting values by about 4 weeks after dosing. Water intake displayed a triphasic pattern: at first it was slightly increased (Days 1 to 3), then reduced (on Days 4 to 12) and finally increased again throughout the remainder of the test period. The absolute and/or relative weights of thymus, testicles, ventral prostate and interscapular brown fat were significantly decreased at termination. These results indicate that the LD50-value for TCDD in the male, adult Han/Wistar rat is substantially above 1400 micrograms/kg, and that suppression of appetite is the principal phenomenon responsible for TCDD-induced body weight reduction.

Statistics

0100200'95'97'99'01'03'05'07'09'11'13'15'17
Citations per Year

547 Citations

Semantic Scholar estimates that this publication has 547 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Pohjanvirta1987HanWistarRA, title={Han/Wistar rats are exceptionally resistant to TCDD. I.}, author={Raimo Pohjanvirta and Jouni T. Tuomisto and Terttu Vartiainen and Karl K. Rozman}, journal={Pharmacology & toxicology}, year={1987}, volume={60 2}, pages={145-50} }