Hammering out details: regulating metal levels in eukaryotes.

  title={Hammering out details: regulating metal levels in eukaryotes.},
  author={Kate M Ehrensberger and Amanda Jane Bird},
  journal={Trends in biochemical sciences},
  volume={36 10},
The transition metals zinc, iron and copper are common constituents in a wide range of proteins. Although these metals are all essential for life, when present in excess, they are frequently toxic to cell growth and viability. Therefore, all organisms rely on sophisticated mechanisms to maintain optimal levels of each metal. Genes that encode metal transport or storage proteins are often regulated at the transcriptional level in response to changes in metal status. In this review, we focus on… CONTINUE READING

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