Hammerhead ribozymes targeted against cyclin E and E2F1 cooperate to down-regulate coronary smooth muscle cell proliferation.

@article{Grassi2005HammerheadRT,
  title={Hammerhead ribozymes targeted against cyclin E and E2F1 cooperate to down-regulate coronary smooth muscle cell proliferation.},
  author={Gabriele Grassi and Ayn Schneider and Sharon Engel and Giorgia Racchi and Reinhard Kandolf and Anne Kuhn},
  journal={The journal of gene medicine},
  year={2005},
  volume={7 9},
  pages={1223-34}
}
BACKGROUND Anti-proliferative drugs released from endo-vascular stents have substantially contributed to reduce in-stent restenosis rates in coronary arteries bearing single primary lesions by down-regulating coronary smooth muscle cell (CSMC) growth. However, the considerably lower drug efficacy shown in treatment of more complex coronary lesions suggests that alternative anti-proliferative approaches can be beneficial. Thus, we explored the use of hammerhead ribozymes as tools to knock down… CONTINUE READING
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