Hammerhead Ribozyme against γ‐Glutamylcysteine Synthetase Attenuates Resistance to Ionizing Radiation and Cisplatin in Human T98G Glioblastoma Cells

@inproceedings{Tani2002HammerheadRA,
  title={Hammerhead Ribozyme against γ‐Glutamylcysteine Synthetase Attenuates Resistance to Ionizing Radiation and Cisplatin in Human T98G Glioblastoma Cells},
  author={Masaharu Tani and Shinji Goto and Kensaku Kamada and Katsuharu Mori and Yoshishige Urata and Yoshito Ihara and Hiroshi Kijima and Y. Ueyama and Shobu Shibata and Takahito Kondo},
  booktitle={Japanese journal of cancer research : Gann},
  year={2002}
}
Glioblastoma cells are highly malignant and show resistance to ionizing radiation, as well as anti-cancer drugs. This resistance to cancer therapy is often associated with a high concentration of glutathione (GSH). In this study, the effect of continuous down-regulation of gamma-glutamylcysteine synthetase (gamma-GCS) expression, a rate-limiting enzyme for GSH synthesis, on resistance to ionizing radiation and cisplatin (CDDP) was studied in T98G human glioblastoma cells. We constructed a… CONTINUE READING

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