Hamartomatous adenoma of the nonpigmented ciliary epithelium arising in iris-ciliary body coloboma. Light and electron microscopic observations.

  title={Hamartomatous adenoma of the nonpigmented ciliary epithelium arising in iris-ciliary body coloboma. Light and electron microscopic observations.},
  author={James Randall Patrinely and Ramon L. Font and Robert J. Campbell and Dennis M. Robertson},
  volume={90 12},
A 2 1/2-year-old boy had a slowly enlarging mass at the site of a typical iris-ciliary body coloboma for 2 years. The mass was excised partially by iridocyclectomy. By light microscopy, the tumor cells were embedded in a rich mucoid stroma that contained abundant hyaluronidase-sensitive acid mucopolysaccharides. By electron microscopy the tumor showed light and dark cells with interdigitating cell membranes, desmosomes, gap junctions, multilaminar basement membrane, and numerous extracellular… 
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Congenital adenoma of the iris and ciliary body: light and electron microscopic observations.
A 23-year-old man had a lesion in the right inferior iris which appeared to have enlarged since it was first seen when the patient was aged 5 years, and it is believed that this neoplasm represents a congenital adenoma of the ciliary body and iris.
Fetal adenoma of the pigmented ciliary epithelium associated with persistent hyperplastic primary vitreous.
The authors report the youngest presentation of a pigment epithelium adenoma, the only well-documented case associated with persistent hyperplastic primary vitreous, and the only documentation of annulate lamellae in a ciliary body tumor.
Adenoma of the non-pigmented ciliary epithelium: a rare intraocular tumor with unusual immunohistochemical findings.
Myofilaments are not totally unexpected in ciliary adenomas; however, such a diffuse and strong positivity for smooth muscle actin, as in the present case, has only been observed in one case before, but should be considered in the differential diagnosis of these neoplasms.
Pleomorphic adenocarcinoma of ciliary epithelium simulating an epibulbar tumor.
A 72-year-old woman had epibulbar nodules and a blind eye following trauma in childhood. Histologic examination disclosed a pleomorphic adenocarcinoma of ciliary epithelium with invasion of the
Uncommon cause of juvenile cataract: adenoma of the nonpigmented ciliary epithelium.
A ciliary adenoma of the nonpigmented ciliary epithelium developed in a 36-year-old woman, causing decreased visual acuity and a total cataract in the involved eye and the associated PHPV suggests a congenital origin.
Glioneuroma associated with colobomatous dysplasia of the anterior uvea and retina. A case simulating medulloepithelioma.
The tumor was rediagnosed as glioneuroma, which in this case was part of a widespread colobomatous dysplasia of the anterior uvea and retina, and the patient is alive without metastases or local recurrence 2 years following enucleation and subtotal removal of the lesion.
Acquired neoplasms of the nonpigmented ciliary epithelium (adenoma and adenocarcinoma).
BACKGROUND/PURPOSE Acquired neoplasms of the nonpigmented ciliary body epithelium (NPCE) are rare, and most information about them has come from single case reports. This study was undertaken to
Metastatic colloid carcinoma versus primary carcinoma of the ciliary epithelium.
Ocular metastases developed from breast carcinomas in two women 7 and 19 years after their mastectomies. They were both ciliary body metastases that had eroded through the root of the iris to present
Ultrastructural and immunohistochemical features of coronal adenomas.
It is confirmed that coronal adenomas develop from nonpigmented ciliary epithelium and that the extracellular material of these tumors contains components normally present in basement membranes.
Update of sporadic microphthalmos and coloboma. Non-inherited anomalies.
  • M. Warburg
  • Biology, Medicine
    Ophthalmic paediatrics and genetics
  • 1992
This is a survey of non-inherited, sporadic microphthalmos, which may occur in the Goldenhar, CHARGE and VATER associations and may be due to teratological agents, for instance maternal ingestion of drugs, maternal infection, fever or irradiation.


[Contribution to the epithelial tumors of the ciliary body (clinical, histopathological and electronmicroscopical observation) (author's transl)].
An adenoma of the non pigmented epithelium of the ciliary body was supposed to be an irisciliary body melanoma (32P-test positive) and was treated by irido-cyclectomy and showed unequivocal the benignant character of this tumor.
[Adenoma of the ciliary epithelium of unusual structure and localisation (authors transl)].
The authors describe an adenoma of the ciliary epithelium of low degree of malignacy. The tumor is clinically and histologically remarkable because of its uncommom site behind the iris and the
The incidence and histology of Fuchs's adenoma.
In a series of 100 eyes received from the Medical Eye Bank of Maryland and the Eye Bank for Sight Restoration of New York, 16 small benign ciliary-body tumors were found in 14 eyes from 12 individual patients, and support to the theory of invagination concerning their origin is given.
The amount of hyaluronic acid present in synovial fluid or vitreous humour is, in fact, so small, in spite of the high viscosity of the fluids, that the problem of finding the cells of origin may be simply solved.
Benign adenoma of the ciliary epithelium with tumour seeding.
  • R. Haddad, H. Slezak
  • Medicine
    Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
  • 1979
Tumour seeding was a remarkable finding, and is a result of disruption of the epithelial lining due to active production of mucopolysaccharides by tumour cells.
Iridocyclectomy for benign tumors of the ciliary body.
agree with the premise on which the conclu­ sion is based. Preoperative antibiotics elimi­ nate the easily destroyed bacteria from the external eye and allow the resistant bacteria to multiply and
Adenom des Ziliarkörpers
An adenoma of the non-pigmented ciliary body was removed locally; 15 years later the eye was enucleated. The globe contained a small tumor with similar histological features but invasive growth.
Intercellular junctions in the ciliary epithelium.
The fine structure of the intercellular junctions in the ciliary epithelium of rhesus monkeys and rabbits was studied with conventional electron microscopy of thin-sectioned specimens and the freeze-fracturing technique and found that gap junctions are ubiquitous and particularly numerous at the interface between pigmented and nonpigmented layers; this finding indicates that the cells of the ciletium are joined in a metabolic syncytium.
Ocular histology;: A text and atlas
text (the previous editions were all written by Sir Stewart Duke-Elder). The book's new format consists of a larger size and double columns. Many of the old figures have been retained, and updated