Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility.

@article{Bourdi2001HalothaneinducedLI,
  title={Halothane-induced liver injury in outbred guinea pigs: role of trifluoroacetylated protein adducts in animal susceptibility.},
  author={Mohammed Bourdi and Hamid R Amouzadeh and Thomas H. Rushmore and Jackie Martin and Lance R. Pohl},
  journal={Chemical research in toxicology},
  year={2001},
  volume={14 4},
  pages={362-70}
}
Halothane causes a mild form of liver injury in guinea pigs that appears to model the hepatotoxicity seen in approximately 20% of patients treated with this drug. In previous studies, it was concluded that the increased susceptibility of some outbred guinea pigs to halothane-induced liver injury is not caused by their inherent ability to metabolize halothane to form toxic levels of trifluoroacetylated protein adducts in the liver. In this study, we reevaluated the role of trifluoroacetylated… CONTINUE READING