Halothane-induced intracellular calcium release in cholinergic cells.

  title={Halothane-induced intracellular calcium release in cholinergic cells.},
  author={Renato Santiago Gomez and Cristina Guatimosim and Jim Barbosa and Andr{\'e} Ricardo Massensini and Marcus Vin{\'i}cius Gomez and Marco A M Prado},
  journal={Brain research},
  volume={921 1-2},
Low concentrations of halothane and isoflurane can release acetylcholine in an extracellular Ca(2+)-independent manner. In the present study, a cholinergic cell line (SN56) was used to examine whether release of calcium from intracellular stores occurs in the presence of halothane. Changes in intracellular calcium concentration ([Ca(2+)](i)) were measured using fluo-3, a fluorescent calcium-sensitive dye and laser scanning confocal microscopy. Halothane, at sub-anesthetic concentrations (14, 28… CONTINUE READING