Halothane and Methoxyflurane — A Comparison of Their Effects on Cardiac Pacemaker Fibers

@article{Reynolds1970HalothaneAM,
  title={Halothane and Methoxyflurane — A Comparison of Their Effects on Cardiac Pacemaker Fibers},
  author={A. Reynolds and J. F. Chiz and A. Pasquet},
  journal={Anesthesiology},
  year={1970},
  volume={33},
  pages={602-610}
}
  • A. Reynolds, J. F. Chiz, A. Pasquet
  • Published 1970
  • Medicine
  • Anesthesiology
  • Halothane and methoxyflurane have some very similar and some very different effects on primary and latent pacemaker fibers. On fibers of the sinoatrial node, halothane has a negative chronotropic action winch is not prevented by atropine. The effect of methoxyflurane is biphasic: an initial, brief acceleration precedes the negative chronotropic action. Both compounds can cause complete cessation of electrical activity of nodal fibers “ in vitro,” and this may occur with relatively low… CONTINUE READING

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