Haloperidol prevents ketamine- and phencyclidine-induced HSP70 protein expression but not microglial activation.

@article{Nakki1996HaloperidolPK,
  title={Haloperidol prevents ketamine- and phencyclidine-induced HSP70 protein expression but not microglial activation.},
  author={R Nakki and Jeremy Nickolenko and Jing Ning Chang and Stephen M Sagar and Frank R. Sharp},
  journal={Experimental neurology},
  year={1996},
  volume={137 2},
  pages={234-41}
}
Noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists, inclu ding ketamine and phencyclidine (PCP), produce abnormal intracellular vacuoles in posterior cingulate and retrosplenial cortical neurons in the rat. Ketamine also induces 70-kDa heat shock protein (HSP70) expression in pyramidal neurons in the posterior cingulate and retrosplenial cortex and, as shown by this study, activates microglia in the retrosplenial cortex of the rat. Whereas HSP70 protein expression was induced with… CONTINUE READING

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