Haloperidol plasma levels and dose optimization.

  title={Haloperidol plasma levels and dose optimization.},
  author={William H. Coryell and Del D. Miller and Paul J. Perry},
  journal={The American journal of psychiatry},
  volume={155 1},
OBJECTIVE This study was designed to test the practical utility of haloperidol plasma level determinations in the management of schizophrenic patients who show poor initial responses to haloperidol. METHOD Inpatients with acute exacerbations of DSM-III schizophrenia (N = 66) were randomly assigned to receive fixed haloperidol doses intended to achieve plasma levels of 8-18 ng/ml or of 25-35 ng/ml. Patients whose scores on the Brief Psychiatric Rating Scale (BPRS) failed to improve by at least… CONTINUE READING

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