Haloperidol plasma levels and clinical response in paranoid schizophrenics

  title={Haloperidol plasma levels and clinical response in paranoid schizophrenics},
  author={Paul Linkowski and Philippe Hubain and Remy von Frenckell and Julien Mendlewicz},
  journal={European archives of psychiatry and neurological sciences},
The relationship between haloperidol plasma levels, plasma prolactin, and therapeutic efficacy was evaluated in 20 paranoid schizophrenics in a fixed-dose study for 6 weeks. We found a significant intrapatient cross-correlation of therapeutic efficacy, as measured by decrease in MSS and BPRS rating scales and time-dependent haloperidol and pro lactin changes, which were tested at weekly intervals. However, no significant curvilinear relationship was present between steady-state haloperidol… CONTINUE READING

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