Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems.

@article{Hanson1981HaloperidolinducedRO,
  title={Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems.},
  author={Glen R. Hanson and L Alphs and W. Wolf and Ross Levine and Walter Lovenberg},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1981},
  volume={218 2},
  pages={568-74}
}
Protracted blockade of dopamine receptors by haloperidol has been shown to cause a reduction in nigral content of substance P-like immunoreactivity (SPLI). This pharmacological effect is used to study the mechanisms whereby the dopaminergic and substance P systems interact. Data presented in this paper suggest that 1) blockade of dopamine postsynaptic receptors alters nigral SPLI levels associated with the substance P striatal-nigral loop, 2) destruction of the nigral-striatal dopaminergic… CONTINUE READING

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