Haloperidol-induced morphological changes in striatum are associated with glutamate synapses.

@article{Meshul1994HaloperidolinducedMC,
  title={Haloperidol-induced morphological changes in striatum are associated with glutamate synapses.},
  author={Charles K. Meshul and Regina K. Stallbaumer and Barry Taylor and Aaron J Janowsky},
  journal={Brain research},
  year={1994},
  volume={648 2},
  pages={181-95}
}
Sub-chronic treatment with the typical neuroleptic, haloperidol (0.5 mg/kg/d, s.c.), but not the atypical neuroleptic, clozapine (35 mg/kg/day, s.c.), causes an increase in synapses containing a perforated postsynaptic density (referred to as 'perforated' synapses) and in dopamine (DA) D2 receptors within the caudate nucleus [46]. To determine if these perforated synapses are glutamatergic, we systemically co-administered MK-801 (0.3 mg/kg/day for 2 weeks), a non-competitive antagonist at the N… CONTINUE READING

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