Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32.

@article{Snchez2014HaloperidolinducedNE,
  title={Haloperidol-induced Nur77 expression in striatopallidal neurons is under the control of protein phosphatase 1 regulation by DARPP-32.},
  author={Natalia A S{\'a}nchez and Renata Dos-Santos Coura and Olivia Engmann and Lucile Marion-Poll and Sophie Longueville and Denis Herv{\'e} and Mar{\'i}a Estela Andr{\'e}s and Jean-Antoine Girault},
  journal={Neuropharmacology},
  year={2014},
  volume={79},
  pages={559-66}
}
Impaired dopaminergic signaling in the striatum is involved in diseases as diverse as Parkinson's disease, addiction, and schizophrenia. An important pathophysiological aspect is the loss of balance between striatopallidal and striatonigral pathways. Nur77 is an orphan nuclear receptor and dopamine-regulated immediate-early gene. Classical antipsychotic drugs widely used in the treatment of schizophrenia, such as haloperidol, increase Nur77 mRNA expression in the striatum. However, little is… CONTINUE READING

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DARPP-32: molecular integration of phosphorylation potential

Cellular and Molecular Life Sciences • 2008
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