Haloperidol disrupts opioid-antinociceptive tolerance and physical dependence.

@article{Yang2011HaloperidolDO,
  title={Haloperidol disrupts opioid-antinociceptive tolerance and physical dependence.},
  author={Cheng Yang and Yan Chen and Lei Tang and Zaijie Jim Wang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2011},
  volume={338 1},
  pages={164-72}
}
Previous studies from our laboratory and others have implicated a critical role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in opioid tolerance and dependence. Translational research targeting the CaMKII pathway is challenging, if not impossible, because of a lack of selective inhibitors. We discovered in a preliminary study that haloperidol… CONTINUE READING