Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers.

@article{Llerena1992HaloperidolDI,
  title={Haloperidol disposition is dependent on the debrisoquine hydroxylation phenotype: increased plasma levels of the reduced metabolite in poor metabolizers.},
  author={Adri{\'a}n Llerena and Marja Liisa Dahl and Britta Ekqvist and Leif Bertilsson},
  journal={Therapeutic drug monitoring},
  year={1992},
  volume={14 3},
  pages={261-4}
}
We have previously shown that the disposition of haloperidol is decreased in poor (PM) compared to extensive (EM) metabolizers of debrisoquine. We now report that the plasma levels of the reduced metabolite of haloperidol, after a single 2- or 4-mg oral dose of the parent drug, are significantly higher in PM than in EM of debrisoquine. As PM have higher concentrations of haloperidol than EM, more of the reduced metabolite should be formed, since the formation of reduced haloperidol from… CONTINUE READING

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