Haloperidol counteracts the ketamine-induced disruption of processing negativity, but not that of the P300 amplitude.

  title={Haloperidol counteracts the ketamine-induced disruption of processing negativity, but not that of the P300 amplitude.},
  author={Bob Oranje and Christine Gispen-de Wied and Herman G. M. Westenberg and Chantal Kemner and Marinus Nicholaas Verbaten and Ren{\'e} S. Kahn},
  journal={The international journal of neuropsychopharmacology},
  volume={12 6},
Antagonists of the N-methyl-D-aspartate (NMDA) receptors such as ketamine, induce abnormalities in healthy subjects similar to those found in schizophrenia. However, recent evidence, suggests that most of the currently known NMDA antagonists have a broader receptor profile than originally thought. Besides exerting an antagonistic effect on NMDA receptors, they have agonistic effects on dopamine D2 receptors. Can haloperidol (D2 antagonist) counteract the disruptive effects of ketamine on… CONTINUE READING
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