Haloperidol blocks dorsal striatum activity but not analgesia in a placebo paradigm.

@article{Wrobel2014HaloperidolBD,
  title={Haloperidol blocks dorsal striatum activity but not analgesia in a placebo paradigm.},
  author={Nathalie Wrobel and Katja Wiech and K. Forkmann and Christoph Ritter and U. Bingel},
  journal={Cortex; a journal devoted to the study of the nervous system and behavior},
  year={2014},
  volume={57},
  pages={60-73}
}
Although placebo analgesia has been associated with an engagement of the endogenous opioid system there is growing evidence from neuropharmacological studies for an involvement of additional neurotransmitter systems. An increased dopaminergic neurotransmission in the ventral basal ganglia that has been found during placebo analgesia suggests a role for the dopaminergic system (Scott et al., 2007). It is, however, unclear whether striatal dopaminergic activity is causally involved in this type… CONTINUE READING