Haloperidol and clozapine treatment and their effect onM-chlorophenylpiperazine-mediated responses in schizophrenia: implications for the mechanism of action of clozapine

Abstract

Since clozapine is, in contrast to conventional neuroleptics, effective in treatment refractory schizophrenic patients its mechanism of action may be different from that of typical neuroleptics. Clozapine has been shown to display the highest binding affinity of all neuroleptics to one of the serotonin (5-hydroxytryptamine, 5HT) receptor subtypes, i.e., the… (More)
DOI: 10.1007/BF02245012

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