Haloperidol and clozapine have dissociable effects in a model of attentional performance deficits induced by blockade of NMDA receptors in the mPFC

@article{Baviera2007HaloperidolAC,
  title={Haloperidol and clozapine have dissociable effects in a model of attentional performance deficits induced by blockade of NMDA receptors in the mPFC},
  author={Marta Baviera and Roberto William Invernizzi and Mirjana Carli},
  journal={Psychopharmacology},
  year={2007},
  volume={196},
  pages={269-280}
}
Cognitive impairment in schizophrenia is particularly evident in the domains of attention and executive functions. Atypical antipsychotics are somewhat more effective than conventional antipsychotics in improving cognitive functioning in these patients. The aim of this study was to compare the effects of conventional and atypical antipsychotics in a model of attentional performance deficit of schizophrenia induced by blockade of N-methyl-d-aspartate (NMDA) receptors in the medial prefrontal… CONTINUE READING

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The aim of this study was to compare the effects of conventional and atypical antipsychotics in a model of attentional performance deficit of schizophrenia induced by blockade of N - methyl - d - aspartate ( NMDA ) receptors in the medial prefrontal cortex .
The aim of this study was to compare the effects of conventional and atypical antipsychotics in a model of attentional performance deficit of schizophrenia induced by blockade of N - methyl - d - aspartate ( NMDA ) receptors in the medial prefrontal cortex .
The aim of this study was to compare the effects of conventional and atypical antipsychotics in a model of attentional performance deficit of schizophrenia induced by blockade of N - methyl - d - aspartate ( NMDA ) receptors in the medial prefrontal cortex .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
SchizophreniaMay be treated byClozapine
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
Antipsychotic AgentsTherapeutic class ofClozapine
The effects on “ impulsivity ” and “ compulsive perseveration ” in a rat model of attentional and executive deficit of schizophrenia might differentiate conventional and atypical antipsychotics . Antagonistic activity at 5-HT2A receptors may best explain the facilitatory effects of clozapine on cognition .
The aim of this study was to compare the effects of conventional and atypical antipsychotics in a model of attentional performance deficit of schizophrenia induced by blockade of N - methyl - d - aspartate ( NMDA ) receptors in the medial prefrontal cortex .
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