Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels

@article{Jung2015HaloperidolAR,
  title={Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels},
  author={Ivo Em{\'i}lio da Cruz Jung and Alencar Kolinski Machado and Ivana Beatrice M{\^a}nica da Cruz and Fernanda Barbisan and Ver{\^o}nica Farina Azzolin and Thiago B. Duarte and Marta Maria Medeiros Frescura Duarte and Pedro Ant{\^o}nio Schmidt do Prado-Lima and Guilherme Vargas Bochi and Gustavo Scola and Rafael Noal Moresco},
  journal={Psychopharmacology},
  year={2015},
  volume={233},
  pages={1715-1723}
}
Antipsychotic drugs, such as haloperidol and risperidone, are used in long-term treatment of psychiatric patients and thus increase the risk of obesity and other metabolic dysfunctions. Available evidence suggests that these drugs have pro-inflammatory effect, which contributes to the establishment of endocrine disturbances. However, results yielded by extant studies are inconsistent. Therefore, in this work, we tested the in vitro effects of different high concentrations of haloperidol and… CONTINUE READING
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