Halogenation strategies in natural product biosynthesis.

  title={Halogenation strategies in natural product biosynthesis.},
  author={Christopher S. Neumann and Danica Galoni{\'c} Fujimori and Christopher T Walsh},
  journal={Chemistry & biology},
  volume={15 2},
Halogenation is a frequent modification of secondary metabolites and can play a significant role in establishing the bioactivity of a compound. Enzymatic halogenation through oxidative mechanisms is the most common route to these metabolites, though direct halogenation via halide anion incorporation is also known to proceed through both enzymatic and nonenzymatic pathways. In this article, we review the current state of knowledge regarding the mechanisms of these transformations, highlight… CONTINUE READING
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