Halogen bonding controls selectivity of FRET substrate probes for MMP-9.

@article{Tranchant2014HalogenBC,
  title={Halogen bonding controls selectivity of FRET substrate probes for MMP-9.},
  author={Isabelle Tranchant and Laura Vera and Bertrand Czarny and Mehdi Amoura and Evelyne Cassar and Fabrice Beau and Enrico A Stura and Vincent Dive},
  journal={Chemistry & biology},
  year={2014},
  volume={21 3},
  pages={408-13}
}
Matrix metalloproteinases (MMPs) are a large family of zinc-dependent endoproteases that catalyze cleavage of extracellular matrix and nonmatrix proteins. MMPs play a role in tissue remodeling, and their uncontrolled activity is associated with number of diseases, including tumor metastasis. Thus, there is a need to develop methods to monitor MMP activity… CONTINUE READING