Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study.

@article{Abramovitch2004HalofuginoneIA,
  title={Halofuginone inhibits angiogenesis and growth in implanted metastatic rat brain tumor model--an MRI study.},
  author={Rinat Abramovitch and Anna Itzik and H Yael Meller Harel and Arnon Nagler and Israel Vlodavsky and Tali Siegal},
  journal={Neoplasia},
  year={2004},
  volume={6 5},
  pages={480-9}
}
Tumor growth and metastasis depend on angiogenesis; therefore, efforts are made to develop specific angiogenic inhibitors. Halofuginone (HF) is a potent inhibitor of collagen type alpha1(I). In solid tumor models, HF has a potent antitumor and antiangiogenic effect in vivo, but its effect on brain tumors has not yet been evaluated. By employing magnetic resonance imaging (MRI), we monitored the effect of HF on tumor progression and vascularization by utilizing an implanted malignant fibrous… CONTINUE READING