Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.

@article{Sundrud2009HalofuginoneIT,
  title={Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.},
  author={Mark S. Sundrud and Sergei B. Koralov and Markus Feuerer and Dinis Pedro Calado and Aimee Elhed Kozhaya and Ava Rhule-Smith and Rachel E Lefebvre and Derya Unutmaz and Ralph Mazitschek and Hanspeter Waldner and Malcolm R Whitman and Tracy Keller and Anjana Rao},
  journal={Science},
  year={2009},
  volume={324 5932},
  pages={1334-8}
}
A central challenge for improving autoimmune therapy is preventing inflammatory pathology without inducing generalized immunosuppression. T helper 17 (TH17) cells, characterized by their production of interleukin-17, have emerged as important and broad mediators of autoimmunity. Here we show that the small molecule halofuginone (HF) selectively inhibits mouse and human TH17 differentiation by activating a cytoprotective signaling pathway, the amino acid starvation response (AAR). Inhibition of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 138 extracted citations

Similar Papers

Loading similar papers…