Halofuginone improves muscle-cell survival in muscular dystrophies.


Halofuginone has been shown to prevent fibrosis via the transforming growth factor-β/Smad3 pathway in muscular dystrophies. We hypothesized that halofuginone would reduce apoptosis--the presumed cause of satellite-cell depletion during muscle degradation-in the mdx mouse model of Duchenne muscular dystrophy. Six-week-old mdx mouse diaphragm exhibited… (More)
DOI: 10.1016/j.bbamcr.2014.03.025


Cite this paper

@article{Bodanovsky2014HalofuginoneIM, title={Halofuginone improves muscle-cell survival in muscular dystrophies.}, author={Anna Bodanovsky and Noga Guttman and Hila Barzilai-Tutsch and Ola Genin and Oshrat Levy and Mark Pines and Orna Halevy}, journal={Biochimica et biophysica acta}, year={2014}, volume={1843 7}, pages={1339-47} }