Halofugine prevents cutaneous graft versus host disease by suppression of Th17 differentiation.

Abstract

Halofuginone, isolated from Dichroa febreifuga, is a potent inhibitor of skin collagen in chronic graft-versus-host disease (GVHD). To evaluate the effect of halofuginone on the development of cutaneous GVHD, we developed a murine model based on BALB/c (H-2d) as recipients with transplantation of C57BL/6(H-2b) bone marrow plus splenocytes. Halofuginone or… (More)
DOI: 10.1179/1607845412Y.0000000016

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